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Antrodia camphorata Contact Us

Introduction

Antrodia cinnamomea, also known as “ Niu-chang-chih ” or “Chang-chih ” is a medicinal fungus unique to Taiwan. Our fermentation techniques can offer an alternative production of A. cinnamomea in the form of mycelium or whole broth.Antrodia cinnamomea has a complete safety and functional assessment profile.

Safety Profile

  • Genotoxicity
  • Acute toxicity per batch production
  • 28-day subacute toxicity
  • 90-day subacute toxicity
  • Teratogenicity toxicity

Significance

  • Health Food Certificate No. 182: Enhances liver rejuvenation
  • ?12% polysaccharide content
  • Over 28 published scientific studies
  • Bioactive compound: Antrosterol, AntrocinnamomideR,AntroterpeneR
  • Antrosterol : The only pure compound from Antrodia cinnamomeawhich has been experimented in the animal model.
  • Customerized formulas available

Structure

Antrosterol
Antrocinnamomide
Antrostero

Specificationse

AppearancePowder form
ColourRed-brown
Moisture? 5%
Polysaccharide 12%
Total Plate Count (TPC)? 5×104 cfu/g
ColiformNegative
Staphylococcus aureueNegative
SalmonellaNegative
Lead (Pb)? 5.0 ppm
Arsenic (As)? 2.0 ppm
Mercury (Hg)? 0.5 ppm
Cadmium (Cd)?0.5 ppm
Cadmium (Cd)?0.5 ppm
Adenosine 0.8 mg/g
Sesamin? 1.2 mg/g
Antrosterol? 1.5 mg/g
Manual Download

Reference

1 Hseu SJ, Chen, CN, Chen. CC. Study on the Host Specificity of Antrodia camphorate. 2000. Taiwanese Journal of Agricultural Chemistry and Food Science. 38(6): 533-539.
2 Chen. CC, Lin WS, Chen, CN, Hseu SJ, Huang SC, Chen YL. 2001. Development of Antrodia camphorate mycelium with submerge culture. Fungi Science. 16(1, 2): 7-22.
3 Chang HL, Chao GR, Chen CC, Mau JL. 2001. Non-volatile taste components of Agaricus blazei, Antrodia camphorata and Cordyceps militaris mycelia. Food Chemistry. 74:203-207.
4 Mau JL, Lin HC, Chen CC. 2002. Antioxidant Properties of Several Medicinal Mushrooms. Journal of Agricultural and Food Chemistry. 50: 6072-6077.
5 Song TY, Yen GC. 2002. Antioxidant Properties of Antrodia camphorata in Submerged Culture. Journal of Agricultural and Food Chemistry. 50: 6072-6077.
6 Mau JL, Huang PN, Haung SJ, Chen CC. 2003. Time course for antioxidants production by Antrodia camphorata in submerged culture. Fungi Science. 18(3, 4): 59-7
7 Song TY, Yen GC. 2003. Protective effects of Fermented Filtrate from Antrodia camphorata in submerged Culture against CCl4-Induced Hepatic Toxicity in Rats. Journal of Agricultural and Food Chemistry. 51: 1571-1577.
8 Dai YY, Chuang CH, Tsai CC, Sio HM, Huang SC, Chen JC, Hu ML. 2003. The Protection of Antrodia camphorata against Acute Hepatotoxicity of Alcohol in Rats. Journal of Food and Drug Analysis. 11(3):177-185.
9 Mau JL, Huang PN, Huang SJ, Chen CC. 2004. Antioxidant properties of methanolic extracts from two kinds of Antrodia camphorata mycelia. Food Chemistry. 86:25-31.
10 Liu JJ, Huang TS, Hsu ML, Chen CC, Lin WS, Lu FJ, Chang WH. 2004. Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action. Toxicology and Applied Pharmacology. 201: 186-193. 11. Anti-HBV principle from the culture broth of Antrodia camphorata (Strain # CCRC-35396). Journal of Chinese Mesicine. 16(1): 57-61.
11 Yang HL, Chen CS, Chang WH, Lu FJ, Lai YC, Chen CC, Hseu TH, Kuo CT, Hseu YC. 2006. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorate. Cancer Letters. 231: 215-227.
12 Yang HL, Hseu YC, Chen JY, Yech YJ, Lu FJ, Wang HH, Lin PS, Wang BC. 2006. Antrodia Camphorata in Submerged Culture Protects Low Density Lipoproteins Against Oxidative Modification. The American Journal of Chinese Medicine. 34(2): 217-231.
13 Tsai MC, Song TY, Shih PH, Yen GC. 2007. Antioxidant properties of water-soluble polysaccharides from Antrodia cinnamomea in submerged culture. Food Chemistry. 104: 1115-1122.
14 Huang SJ, Mau JL. 2007. Antioxidant properties of methanolic extracts from Antrodia camphorata with various doses of γ-irradiation. Food Chemistry .105: 1702-1710. 16. Chen CC, Liu YW, Ker YB, Wu YY, Lai EY, Chyau CC, Hseu TH, Peng RY. 2007. Chemical Characterization and Anti-inflammatory Effect of Polysaccharides Fractionated from Submerge-Cultured Antrodia camphorata Mycelia. Journal of Agricultural and Food Chemistry. 55: 5007-5012.
15 Chen CC, Liu YW, Ker YB, Wu YY, Lai EY, Chyau CC, Hseu TH, Peng RY. 2007. Chemical Characterization and Anti-inflammatory Effect of Polysaccharides Fractionated from Submerge-Cultured Antrodia camphorata Mycelia. Journal of Agricultural and Food Chemistry. 55: 5007-5012.
16 Chen CC, Chyau CC, Hseu TH. 2007. Production of a COX-2 inhibitor, 2,4,5-trimethoxybenzaldehyde, with submerged cultured Antrodia camphorate. Letters in Applied Microbiology 44: 387-392.
17 Wu YY, Chen CC, Chyau CC, Chung SY, Liu YW. 2007. Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorate. Acta Pharmacol Sin. 28(2): 258-267.
18 Cheng PC, Hsu CY, Chen CC, Lee KM. 2008. In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni. Toxicology and Applied Pharmacology 227: 291-298.
19 Chen YJ, Cheng PC, Lin CN, Liao HF, Chen YY, Chen CC, Lee KM. 2008. Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni. International Immunopharmacology. 8: 458-467.
20 Chien CC, Tsai ML, Chen CC. 2008. Effect on Tyrosinase Activity by the Extracts of Ganoderma lucidum and Related Mushrooms. Mycopathologia. 166: 117-120.
21 Pan JH, Chen YS, Sheen LY, Chiang BH. 2008. Large-scale submerged fermentation of Antrodia cinnamomea for anti-hepatoma activity. Journal of Science of Food and Agriculture. 88: 2223-2230.
22 Chen YS, Pan JH, Chiang EJ, Sheen LY. 2008. Ethanolic extracts of Antrodia cinnamomea mycelia fermented at varied times and scales have differential effects on hepatoma cells and normal primary hepatocytes. Journal of Food Science. 73(7): H179–H185.
23 Shao YY, Chen CC, Wang HY, Chiu HL, Hseu TH, Kuo YH. 2011. Chemical constituents of Antrodia camphorata submerged whole broth. Natural Product Research. 22(13): 1151-1157.
24 Yang CM, Zhou YJ, Wang RJ, Hu ML. 2009. Anti-angiogenic effects and mechanisms of polysaccharides from Antrodia cinnamomea with fifferent molecular weights. Journal of Ethnopharmacology. 123: 407-412.
25 Sheu F, Chien PJ, Hsieh KY, Chin KL, Huang WT, Tsao CY, Chen YF, Cheng HC, Chang HH. 2009. Purification, cloning and functional characterization of a novel immunomudulatory protein from Antrodia camphorata (Bitter mushroom) that exhibits TLR2-Dependent NF-κB activation and M1 polarization within murine macrophages. Journal of Agricultural and Food Chemistry. 57: 4130-4141.
26 Huang GJ, Huang SS, Lin SS, Shao YY, Chen CC, Hou WC, Kuo YH. Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3β-ol from Antrodia camphorata submerged whole broth in mice. 2010. Journal of Agricultural and Food Chemistry. 58: 7445-7452.
27 Chen TI, Chen CC, Lin TW, Tsai YT, Nam MK. 2010. A 90-day subchronic toxicological assessement of Antrodia cinnamomea in Sprague-Dawlet rats. Food and Chemical Toxicology. 49: 429-433.